成人骨髓间质干细胞英文

生物细胞储存的技术和方法 2023年07月08日 13:11 71 im

Introduction

　　 Adult bone marrow-derived mesenchymal stem cells (BM-MSCs) are a type of multipotent cells present in the bone marrow stroma. These cells can differentiate into several cell types, including chondrocytes, osteoblasts, adipocytes, and myocytes. BM-MSCs have been of great interest to researchers as they have the potential to be used as a therapeutic tool in regenerative medicine.

Isolation and Characterization of BM-MSCs

　　 BM-MSCs can be isolated from the bone marrow aspirate using methods such as adherent culture, gradient centrifugation, or plastic adherence. The cells are characterized by the expression of CD73, CD90, and CD105 markers and the lack of hematopoietic markers such as CD14, CD34, and CD45. Additionally, BM-MSCs possess the ability to differentiate into several cell types, as mentioned earlier.

Therapeutic Applications of BM-MSCs

　　 BM-MSCs have been used in various preclinical and clinical studies due to their potential applications in the field of regenerative medicine. These cells have shown promising results in the treatment of various diseases, including bone defects, autoimmune diseases, and cardiovascular diseases.

Bone Defects

　　 BM-MSCs have the ability to differentiate into osteoblasts, which are responsible for bone formation. Hence, BM-MSCs have been used to treat bone defects caused by trauma, infection, or tumor resection. Several preclinical and clinical studies have shown that the administration of BM-MSCs can improve bone regeneration and healing.

　　
Autoimmune Diseases

　　 BM-MSCs have immunomodulatory properties and can regulate immune responses. This property of BM-MSCs has been utilized in the treatment of autoimmune diseases such as multiple sclerosis, systemic lupus erythematosus, and rheumatoid arthritis. It has been shown that the administration of BM-MSCs can reduce inflammation and promote tissue repair in these diseases.

　　
Cardiovascular Diseases

　　 BM-MSCs have the potential to differentiate into smooth muscle cells, endothelial cells, and cardiomyocytes. These characteristics of BM-MSCs make them a potential therapeutic tool for the treatment of cardiovascular diseases such as myocardial infarction and ischemic heart disease. Several preclinical studies have shown that the administration of BM-MSCs can improve cardiac function and decrease scar formation.

Conclusion

　　 In conclusion, adult bone marrow-derived mesenchymal stem cells (BM-MSCs) are a promising source of multipotent cells with the potential to be used as a therapeutic tool in regenerative medicine. BM-MSCs can be isolated from the bone marrow aspirate and can differentiate into several cell types. They have been used in various preclinical and clinical studies for the treatment of bone defects, autoimmune diseases, and cardiovascular diseases. The use of BM-MSCs in these applications has demonstrated promising results and further research is warranted to explore their full potential in regenerative medicine.